Role of SMG-1-mediated Upf1 phosphorylation in mammalian nonsense-mediated mRNA decay
نویسندگان
چکیده
منابع مشابه
Upf1 Phosphorylation Triggers Translational Repression during Nonsense-Mediated mRNA Decay
In mammalian cells, nonsense-mediated mRNA decay (NMD) generally requires that translation terminates sufficiently upstream of a post-splicing exon junction complex (EJC) during a pioneer round of translation. The subsequent binding of Upf1 to the EJC triggers Upf1 phosphorylation. We provide evidence that phospho-Upf1 functions after nonsense codon recognition during steps that involve the tra...
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ژورنال
عنوان ژورنال: Genes to Cells
سال: 2013
ISSN: 1356-9597
DOI: 10.1111/gtc.12033